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Clin Cancer Res. 2014 Mar 1;20(5):1064-6. doi: 10.1158/1078-0432.CCR-13-3194. Epub 2014 Feb 17.

Molecular precision chemotherapy: overcoming resistance to targeted therapies?

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1
Author's Affiliation: Technische Universität München, München, Germany.

Abstract

Cytotoxic drugs may have specific effects on oncogenes and their downstream targets. Increase of cancer cell sensitivity due to repression of an oncogene downstream target can be specifically addressed by combined precision chemotherapy, increasing the therapeutic index of chemotherapy and overcoming resistance to highly selective targeted therapies.

PMID:
24536061
DOI:
10.1158/1078-0432.CCR-13-3194
[Indexed for MEDLINE]
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