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J Cell Biol. 2014 Feb 17;204(4):467-76. doi: 10.1083/jcb.201311103.

Protecting the proteome: Eukaryotic cotranslational quality control pathways.

Author information

1
Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.

Abstract

The correct decoding of messenger RNAs (mRNAs) into proteins is an essential cellular task. The translational process is monitored by several quality control (QC) mechanisms that recognize defective translation complexes in which ribosomes are stalled on substrate mRNAs. Stalled translation complexes occur when defects in the mRNA template, the translation machinery, or the nascent polypeptide arrest the ribosome during translation elongation or termination. These QC events promote the disassembly of the stalled translation complex and the recycling and/or degradation of the individual mRNA, ribosomal, and/or nascent polypeptide components, thereby clearing the cell of improper translation products and defective components of the translation machinery.

PMID:
24535822
PMCID:
PMC3926952
DOI:
10.1083/jcb.201311103
[Indexed for MEDLINE]
Free PMC Article

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