Format

Send to

Choose Destination
J Microbiol. 2014 Apr;52(4):350-3. doi: 10.1007/s12275-014-3202-5. Epub 2014 Feb 17.

Identification of secreted virulence factors of Chromobacterium violaceum.

Author information

1
Departamento de BioquĂ­mica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Abstract

Chromobacterium violaceum, a component of tropical soil microbiota, is an opportunistic pathogenic bacterium that can infect humans and other animals. In addition to identifying a large number of genes that demonstrate the vast biotechnological potential of this bacterium, genome sequencing revealed several virulence factors, including different cytolysins, which can be related to its pathogenicity. Here we confirmed these predictions from genomic analyses by identifying, through mass spectrometry, proteins present in the culture supernatant of C. violaceum that may constitute secreted virulence factors. Among them, we identified a secreted collagenase and the product of a gene with sequence similarity to previously characterized bacterial porins.

PMID:
24535738
DOI:
10.1007/s12275-014-3202-5
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center