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Dalton Trans. 2014 Apr 14;43(14):5535-45. doi: 10.1039/c3dt53095g. Epub 2014 Feb 18.

PET imaging with multimodal upconversion nanoparticles.

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1
Comprehensive Cancer Imaging Centre, Department of Surgery and Cancer, Hammersmith Campus, Imperial College London, Du Cane Road, London, W12 0NN, UK. n.long@imperial.ac.uk.

Abstract

A series of new upconversion nanoparticles have been functionalised with tumour-targeting molecules and metal chelates, prepared following standard peptidic and thiol chemistry. The targeting strategy has been delivered via the αvβ3 integrin, which is a heterodimeric cell surface receptor that is up-regulated in a variety of cancers, such as melanoma and breast cancer. The well-known DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) motif allows coordination to the radionuclide (68)Ga. Radiolabelling experiments were optimised under relatively mild conditions, and are rare amongst nanoparticulate materials. In vivo application of these probes in mouse tumour models revealed their potential as specific cancer contrast agents for PET imaging.

PMID:
24535647
DOI:
10.1039/c3dt53095g
[Indexed for MEDLINE]
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