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Eur J Nutr. 2014 Dec;53(8):1637-43. doi: 10.1007/s00394-014-0669-0. Epub 2014 Feb 18.

Dose-response effects of oral guanidinoacetic acid on serum creatine, homocysteine and B vitamins levels.

Author information

1
Exercise Physiology Laboratory, Center for Health, Exercise and Sport Sciences, Stari DIF, Deligradska 27, 11000, Belgrade, Serbia, sergej.ostojic@chess.edu.rs.

Abstract

PURPOSE:

Guanidinoacetic acid (GAA) is an intermediate in the biosynthesis of creatine (Cr), yet its use in human nutrition is limited due to a lack of a clear understanding of its' dose-response effect. Thus, the purpose of this study was to investigate the effect of three different dosages of GAA (1.2, 2.4 and 4.8 g/day) administered for 6 weeks on serum and urinary variables related to GAA metabolism.

METHODS:

Forty-eight healthy volunteers participated in the randomized, placebo-controlled, double-blind, repeated-measure study. At baseline, after 1, 2, 4 and 6 weeks, participants provided both fasting blood samples and 24-h urine.

RESULTS:

GAA intervention significantly increased serum and urinary GAA, Cr and creatinine as compared to placebo (P < 0.05). Differences were found for serum GAA and Cr responses between the three GAA dosages, with high-dose GAA resulting in a greater increase (P < 0.05) in the plasma concentration of both variables as compared to other GAA dosages. In GAA groups, fasting plasma total homocysteine (T-Hcy) increased by 3.5 ╬╝mol/L on average at post-administration, yet no dose-response differences were found between trials. Serum B vitamins were not affected by either placebo or GAA intervention (P > 0.05).

CONCLUSION:

Results indicate that low-to-high dosages of exogenous GAA can increase serum concentrations of Cr and T-Hcy while not depleting the B vitamins pool available for remethylation of homocysteine.

CLINICAL TRIAL REGISTRATION:

ClinicalTrials.gov, identification number NCT01133899.

PMID:
24535415
DOI:
10.1007/s00394-014-0669-0
[Indexed for MEDLINE]

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