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Eur J Med Genet. 2014 Mar;57(4):151-6. doi: 10.1016/j.ejmg.2014.02.002. Epub 2014 Feb 15.

Implementation of genomic arrays in prenatal diagnosis: the Belgian approach to meet the challenges.

Author information

1
Center for Medical Genetics, Universiteit Gent, Belgium.
2
Center for Medical Genetics, Université Libre de Bruxelles, Belgium.
3
Center for Medical Genetics, Universiteit Antwerpen, Belgium.
4
Center for Medical Genetics, Université Catholique de Louvain, Belgium.
5
Center for Medical Genetics, Université de Liège, Belgium.
6
Center for Medical Genetics, Vrije Universiteit Brussel, Belgium.
7
Center for Medical Genetics, Katholieke Universiteit Leuven, Belgium.
8
Center for Medical Genetics, IPG, Charleroi Gosselies, Belgium.
9
Center for Medical Genetics, Katholieke Universiteit Leuven, Belgium. Electronic address: koenraad.devriendt@uzleuven.be.

Abstract

After their successful introduction in postnatal testing, genome-wide arrays are now rapidly replacing conventional karyotyping in prenatal diagnostics. While previous studies have demonstrated the advantages of this method, we are confronted with difficulties regarding the technology and the ethical dilemmas inherent to genomic arrays. These include indication for testing, array design, interpretation of variants and how to deal with variants of unknown significance and incidental findings. The experiences with these issues reported in the literature are most often from single centres. Here, we report on a national consensus approach how microarray is implemented in all genetic centres in Belgium. These recommendations are subjected to constant re-evaluation based on our growing experience and can serve as a useful tool for those involved in prenatal diagnosis.

KEYWORDS:

Copy number variant; Guidelines; Incidental finding; Prenatal diagnosis; Prenatal microarray; Variant of unknown significance

PMID:
24534801
DOI:
10.1016/j.ejmg.2014.02.002
[Indexed for MEDLINE]

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