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Trends Biochem Sci. 2014 Mar;39(3):130-40. doi: 10.1016/j.tibs.2014.01.002. Epub 2014 Feb 15.

Ionic protein-lipid interaction at the plasma membrane: what can the charge do?

Author information

1
National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
2
National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China. Electronic address: cqxu@sibcb.ac.cn.

Abstract

Phospholipids are the major components of cell membranes, but they have functional roles beyond forming lipid bilayers. In particular, acidic phospholipids form microdomains in the plasma membrane and can ionically interact with proteins via polybasic sequences, which can have functional consequences for the protein. The list of proteins regulated by ionic protein-lipid interaction has been quickly expanding, and now includes membrane proteins, cytoplasmic soluble proteins, and viral proteins. Here we review how acidic phospholipids in the plasma membrane regulate protein structure and function via ionic interactions, and how Ca(2+) regulates ionic protein-lipid interactions via direct and indirect mechanisms.

KEYWORDS:

Ca(2+); acidic phospholipids; ionic protein–lipid interaction

PMID:
24534649
DOI:
10.1016/j.tibs.2014.01.002
[Indexed for MEDLINE]
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