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Fitoterapia. 2014 Apr;94:114-9. doi: 10.1016/j.fitote.2014.02.002. Epub 2014 Feb 15.

Phenolic constituents from the leaves of Cratoxylum formosum ssp. pruniflorum.

Author information

1
Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, PR China.
2
Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, PR China.
3
Department of Chemistry, East China Normal University, Shanghai 200062, PR China; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062, PR China; Department of Chemistry, Hoa Lu University, Ninh Binh 40000, Viet Nam.
4
Department of Chemistry, East China Normal University, Shanghai 200062, PR China; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062, PR China.
5
Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, PR China. Electronic address: jfhu@fudan.edu.cn.

Abstract

One (formosumone A, 1) new and fifteen (2-16) known phenolic compounds were isolated from the leaves of Cratoxylum formosum ssp. pruniflorumm, a substitute for the popular bitter nail tea ("Kuding Tea") generally used in Southeast Asia. Their structures were determined by extensive spectroscopic analysis and by comparison with literature data. Compound 1 possesses a rare scaffold of a flavanone coupled with a phloroglucinol moiety, representing the first example of such a scaffold from the Clusiaceae family. Among the isolates, toxyloxanthone B (11) and vismione D (12) were found to show remarkable anti-neuroinflammatory effects by inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells. Additionally, toxyloxanthone B (11) exhibited significant neuroprotective effect against β-amyloid(25-35) (Aβ(25-35))-induced cell viability decrease in SH-SY5Y neuroblastoma cells.

KEYWORDS:

Anti-neuroinflammation; Clusiaceae; Cratoxylum formosum ssp. pruniflorum; Neuroprotection; Phenolic compounds

PMID:
24534445
DOI:
10.1016/j.fitote.2014.02.002
[Indexed for MEDLINE]

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