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Fertil Steril. 2014 Apr;101(4):1129-34. doi: 10.1016/j.fertnstert.2014.01.003. Epub 2014 Feb 15.

Prevalence of androgenic alopecia in patients with polycystic ovary syndrome and characterization of associated clinical and biochemical features.

Author information

1
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California-San Francisco School of Medicine, San Francisco, California. Electronic address: quinnm@obgyn.ucsf.edu.
2
Department of Dermatology, University of California-San Francisco School of Medicine, San Francisco, California.
3
Department of Psychiatry, University of California-San Francisco School of Medicine, San Francisco, California.
4
Cancer Risk Program, University of California-San Francisco School of Medicine, San Francisco, California.
5
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California-San Francisco School of Medicine, San Francisco, California.

Abstract

OBJECTIVE:

To describe the prevalence of androgenic alopecia (AGA) in patients with polycystic ovary syndrome (PCOS) and to characterize associated clinical and biochemical features.

DESIGN:

Cross-sectional study.

SETTING:

Multidisciplinary PCOS clinic at a tertiary academic center.

PATIENT(S):

A total of 254 women with PCOS according to the Rotterdam criteria were systematically examined from 2007 to 2012 by a reproductive endocrinologist, a dermatologist, and a psychologist.

INTERVENTION(S):

Comprehensive dermatologic exams, ultrasonic imaging, serum testing, and Beck Depression Inventory Fast Screen (BDI-FS).

MAIN OUTCOME MEASURES:

Presence of AGA, acne, hirsutism, biochemical hyperandrogenemia, metabolic dysfunction, and clinical depression.

RESULT(S):

Fifty-six of 254 patients with PCOS (22.0%) had AGA. Subjects with PCOS and AGA were more likely to have acne or hirsutism than those without AGA (96.3% vs. 70.6%). Subjects with AGA were more likely to report concern with hair loss (70.4% vs. 37.7%); however, their BDI-FS scores were no different from subjects without AGA. There were no differences between subjects with and without AGA in biochemical hyperandrogenism or metabolic parameters.

CONCLUSION(S):

AGA is prevalent in 22% of subjects meeting diagnostic criteria for PCOS. AGA is associated with other manifestations of clinical hyperandrogenism, but not with greater risk of biochemical hyperandrogenemia or metabolic dysfunction than with PCOS alone.

KEYWORDS:

Polycystic ovary syndrome; androgenic alopecia; clinical hyperandrogenism

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