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Physiol Behav. 2014 Apr 10;128:226-31. doi: 10.1016/j.physbeh.2014.02.002. Epub 2014 Feb 15.

Quinoa extract enriched in 20-hydroxyecdysone affects energy homeostasis and intestinal fat absorption in mice fed a high-fat diet.

Author information

1
INRA, U914, Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France; AgroParisTech, U914, Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France; Institut Biophytis, F-93230 Romainville, France.
2
INRA, U914, Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France; AgroParisTech, U914, Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France.
3
Institut Biophytis, F-93230 Romainville, France; Sorbonne Universités, UPMC, IBPS-BIOSIPE, F-75252 Paris, France.
4
Institut Biophytis, F-93230 Romainville, France.
5
INRA, U914, Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France; AgroParisTech, U914, Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France. Electronic address: quignard@agroparistech.fr.

Abstract

In a previous study, we have demonstrated that a supplementation of a high-fat diet with a quinoa extract enriched in 20-hydroxyecdysone (QE) or pure 20-hydroxyecdysone (20E) could prevent the development of obesity. In line with the anti-obesity effect of QE, we used indirect calorimetry to examine the effect of dietary QE and 20E in high-fat fed mice on different components of energy metabolism. Mice were fed a high-fat (HF) diet with or without supplementation by QE or pure 20E for 3 weeks. As compared to mice maintained on a low-fat diet, HF feeding resulted in a marked physiological shift in energy homeostasis, associating a decrease in global energy expenditure (EE) and an increase in lipid utilization as assessed by the lower respiratory quotient (RQ). Supplementation with 20E increased energy expenditure while food intake and activity were not affected. Furthermore QE and 20E promoted a higher rate of glucose oxidation leading to an increased RQ value. In QE and 20E-treated HFD fed mice, there was an increase in fecal lipid excretion without any change in stool amount. Our study indicates that anti-obesity effect of QE can be explained by a global increase in energy expenditure, a shift in glucose metabolism towards oxidation to the detriment of lipogenesis and a decrease in dietary lipid absorption leading to reduced dietary lipid storage in adipose tissue.

KEYWORDS:

Dietary fat; Ecdysteroids; Energy metabolism; Fat oxidation; Fecal lipid excretion; Food intake; Glucose oxidation; Indirect calorimetry; Obesity

PMID:
24534167
DOI:
10.1016/j.physbeh.2014.02.002
[Indexed for MEDLINE]

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