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Curr Med Chem. 2014;21(20):2266-75.

Medicinal electrochemistry: integration of electrochemistry, medicinal chemistry and computational chemistry.

Author information

1
Centro de Ciências Naturais e Humanas - Universidade Federal do ABC (UFABC), Rua Santa Adélia, 166 - Bairro Bangu - 09210-170 - Santo André - SP - Brazil. kmhonorio@usp.br.

Abstract

Over the last centuries, there were many important discoveries in medicine that were crucial for gaining a better understanding of several physiological processes. Molecular modelling techniques are powerful tools that have been successfully used to analyse and interface medicinal chemistry studies with electrochemical experimental results. This special combination can help to comprehend medicinal chemistry problems, such as predicting biological activity and understanding drug action mechanisms. Electrochemistry has provided better comprehension of biological reactions and, as a result of many technological improvements, the combination of electrochemical techniques and biosensors has become an appealing choice for pharmaceutical and biomedical analyses. Therefore, this review will briefly outline the present scope and future advances related to the integration of electrochemical and medicinal chemistry approaches based on various applications from recent studies.

PMID:
24533810
[Indexed for MEDLINE]

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