Format

Send to

Choose Destination
Anticancer Agents Med Chem. 2014 Mar;14(3):409-17.

Microtubule-targeting anticancer agents from marine natural substance.

Author information

1
School of Pharmaceutical Sciences, Central South University, Changsha 410013, China. wbzeng@hotmail.com.

Abstract

Effective novel therapeutics is urgently needed due to increasing incidence of malignant cancer and drug multi-resistance. Natural products and their derivatives have historically been a source of pharmaceutical leads and therapeutic drugs. Microtubule-targeting compounds are among the most promising candidates in the combat against cancer. In particular, marine natural products (MNPs) have demonstrated exceptional potency and potential as anticancer agents. Drug discovery from MNPs provides a new pathway to develop original anticancer agents. In this review, seven classes of typical MNPs with diverse structures are summarized. Bioactive marine compounds isolated from different organisms including invertebrate animals, algae, fungi and bacteria are also discussed.

PMID:
24533652
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Bentham Science Publishers Ltd.
Loading ...
Support Center