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Indian J Otolaryngol Head Neck Surg. 2014 Jan;66(Suppl 1):359-63. doi: 10.1007/s12070-011-0456-7. Epub 2012 Jan 6.

Management of adult recurrent respiratory papillomatosis with oral acyclovir following micro laryngeal surgery: a case series.

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Department of Otolaryngology and Head and Neck Surgery, St John's Medical College and Hospital, Bangalore, India ; No.15, Type 5, NIMHANS Quarters, Dairy Circle, BRC Campus, Bangalore, 560029 India.
Department of Otolaryngology and Head and Neck Surgery, St John's Medical College and Hospital, Bangalore, India.


To demonstrate the role of oral acyclovir in monthly regimes after microdebrider assisted excision in 3 patients with adult recurrent respiratory papillomatosis (ARRP). Three patients with ARRP who presented to a tertiary referral hospital in stridor were initially treated with a tracheostomy in order to secure airway. On further evaluation by videolaryngoscopy extensive bilateral laryngeal papillomatosis was noted with history of similar conditions in the past for which they were repeatedly operated. They were admitted and underwent Microlaryngeal surgery and laryngeal microdebrider assisted surgery under general anesthesia. Post operatively a course of oral acyclovir at 800 mg/5 times/day for 5 days was administered. On repeat assessment with videolaryngoscopy at monthly intervals a complete remission of the disease was noted with no residual disease at the end of 1 year in 2 cases. One case had a recurrence. Renal parameters were monitored periodically. It may be concluded that the action of anti viral drugs at regular intervals in addition to a short course of oral steroids lead to rapid recovery and prevented latent virus activation within the laryngo tracheal system hence maintaining long term improvement. This can avoid multiple laryngeal surgeries, repeated respiratory emergencies and risk for malignant transformation in the future thereby reducing morbidity and effect on quality of life.


Acyclovir; Adult recurrent respiratory papillomatosis (ARRP); Human papilloma virus (HPV); Papillomatosis

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