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PLoS One. 2014 Feb 12;9(2):e88944. doi: 10.1371/journal.pone.0088944. eCollection 2014.

Low adiposity during early infancy is associated with a low risk for developing dengue hemorrhagic fever: a preliminary model.

Author information

1
Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.
2
Department of Immunology, Research Institute for Tropical Medicine, Manila, Philippines.
3
Department of Epidemiology, Research Institute for Tropical Medicine, Manila, Philippines.
4
Department of Molecular Biology, Research Institute for Tropical Medicine, Manila, Philippines.
5
Department of Virology, Research Institute for Tropical Medicine, Manila, Philippines.
6
Department of Medicine, Research Institute for Tropical Medicine, Manila, Philippines.
7
San Pablo City Health Office, San Pablo, Philippines.
8
Department of Medicine, Research Institute for Tropical Medicine, Manila, Philippines ; Department of Microbiology, Research Institute for Tropical Medicine, Manila, Philippines.

Abstract

Dengue virus (DENV) infections range from asymptomatic or mild illness to a severe and potentially life threatening disease, dengue hemorrhagic fever (DHF). DHF occurs in primary DENV infections during early infancy. A prospective clinical study of DENV infections during infancy was conducted in San Pablo, Philippines. We found that infants who developed DHF with a primary DENV infection had higher WHO weight-for-age z scores before and at the time of infection compared to infants with primary DENV infections who did not develop DHF. In addition, TLR 7/8-stimulated tumor necrosis factor-α (TNF-α) production from myeloid-derived cells was higher among well-nourished infants. Leptin augmented TLR 7/8-mediated TNF-α production in monocytes and decreased intracellular cAMP levels. Circulating leptin levels were elevated during early infancy and correlated with WHO weight-for-age z scores. Our data support a plausible hypothesis as to why well-nourished infants are at risk for developing DHF with their first DENV infection.

PMID:
24533162
PMCID:
PMC3923068
DOI:
10.1371/journal.pone.0088944
[Indexed for MEDLINE]
Free PMC Article

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