Format

Send to

Choose Destination
Int J Health Sci (Qassim). 2013 Nov;7(3):267-75.

Vitamin d deficiency and its association with thyroid disease.

Author information

1
Assistant Professor of Medical Biochemistry, Medical Laboratory Department, Applied Medical Science College, Qassim University, Saudi Arabia.
2
Students in the Medical Laboratory Department, Applied Medical Science College, Qassim University, Saudi Arabia.

Abstract

OBJECTIVES:

Vitamin D deficiency is a global health problem, its role as an immune modulator has been recently emphasized. The evidence is increasingly pointing towards vitamin D significant role in reducing the incidence of autoimmune diseases. However, at this time the research on its role in autoimmune and thyroid disease is not conclusive. We aimed to examine the relationship between hypothyroidism and vitamin D deficiency and to clarify the relation between serum calcium levels with hypothyroid disease.

SUBJECTS AND METHODS:

Serum vitamin D (25-OH) levels were measured in 30 patients with hypothyroidism and 30 healthy subjects, utilizing the spectrophotometric method. Vitamin D deficiency was designated at levels lower than 20 ng/ml. Thyroid hormones (TSH, T3 and T4) and calcium levels were evaluated in all participants.

RESULTS:

Serum 25(OH) vit D was significantly lower in hypothyroid patients than in controls (t=-11.128, P =0.000). Its level was insignificantly decreased in females than male patients (t=- 1.32, P >0.05). Moreover, serum calcium levels recorded a significant decrease in hypothyroid patients when compared to controls (t= -5.69, P = 0.000).

CONCLUSION:

Our results indicated that patients with hypothyroidism suffered from hypovitaminosis D with hypocalcaemia that is significantly associated with the degree and severity of the hypothyroidism. That encourages the advisability of vit D supplementation and recommends the screening for Vitamin D deficiency and serum calcium levels for all hypothyroid patients.

KEYWORDS:

Blood calcium levels; Thyroid diseases; Vit D deficiency

PMID:
24533019
PMCID:
PMC3921055

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center