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Bioinformatics. 2014 Jun 15;30(12):1771-3. doi: 10.1093/bioinformatics/btu097. Epub 2014 Feb 14.

ZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers.

Author information

1
Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605 and Bioinformatics Program, Boston University, 44 Cummington Mall, Boston, MA 02215 USAProgram in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605 and Bioinformatics Program, Boston University, 44 Cummington Mall, Boston, MA 02215 USA.
2
Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605 and Bioinformatics Program, Boston University, 44 Cummington Mall, Boston, MA 02215 USA.

Abstract

SUMMARY:

Protein-protein interactions are essential to cellular and immune function, and in many cases, because of the absence of an experimentally determined structure of the complex, these interactions must be modeled to obtain an understanding of their molecular basis. We present a user-friendly protein docking server, based on the rigid-body docking programs ZDOCK and M-ZDOCK, to predict structures of protein-protein complexes and symmetric multimers. With a goal of providing an accessible and intuitive interface, we provide options for users to guide the scoring and the selection of output models, in addition to dynamic visualization of input structures and output docking models. This server enables the research community to easily and quickly produce structural models of protein-protein complexes and symmetric multimers for their own analysis.

AVAILABILITY:

The ZDOCK server is freely available to all academic and non-profit users at: http://zdock.umassmed.edu. No registration is required.

PMID:
24532726
PMCID:
PMC4058926
DOI:
10.1093/bioinformatics/btu097
[Indexed for MEDLINE]
Free PMC Article

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