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J Leukoc Biol. 2014 Apr;95(4):551-62. doi: 10.1189/jlb.1113599. Epub 2014 Feb 14.

Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors.

Author information

1
1.NIAID, NIH, Bldg. 33, Bethesda, MD 20892, USA. jyewdell@niaid.nih.gov.

Abstract

MHC class I molecules display oligopeptides on the cell surface to enable T cell immunosurveillance of intracellular pathogens and tumors. Speed is of the essence in detecting viruses, which can complete a full replication cycle in just hours, whereas tumor detection is typically a finding-the-needle-in-the-haystack exercise. We review current evidence supporting a nonrandom, compartmentalized selection of peptidogenic substrates that focuses on rapidly degraded translation products as a main source of peptide precursors to optimize immunosurveillance of pathogens and tumors.

KEYWORDS:

antigen processing; compartmentalization; cotranslational degradation; nuclear translation; ribosome; translation

PMID:
24532645
PMCID:
PMC3958739
DOI:
10.1189/jlb.1113599
[Indexed for MEDLINE]
Free PMC Article

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