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Yonsei Med J. 2014 Mar;55(2):417-21. doi: 10.3349/ymj.2014.55.2.417.

Vitamin D levels in children and adolescents with antiepileptic drug treatment.

Author information

1
Department of Pediatrics, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, Seoul 152-703, Korea. bleun@korea.ac.kr.

Abstract

PURPOSE:

This study was to evaluate the relationship of 25(OH)D3 levels with anticonvulsant use and other possible factors in epileptic children and adolescents.

MATERIALS AND METHODS:

We studied 143 patients with epilepsy (90 boys, 53 girls; 11.21±4.49 years), who had been treated with anticonvulsants for more than 1 year. Patients who had taken multiple vitamins before the blood test and those who have the limitation of physical activity (wheelchair-bound) were excluded from the study. We evaluated the difference in vitamin D status according to the type and number of anticonvulsants taken and other factors such as gender, age, intelligence and seizure variables.

RESULTS:

For patients with mental retardation or developmental delay, 25(OH)D3 levels were lower than the levels in patients with normal intelligence quotient levels (p=0.03). 25(OH)D3 levels were lower in patients who had taken anticonvulsants for more than 2 years as compared to those who had taken them for less than 2 years (p=0.03). Those taking oxcarbazepine had significantly lower vitamin D levels than patients taking valproic acid (p=0.01). However, no effects of number of anticonvulsants taken were detectable. More than two-thirds of the patients were diagnosed with osteopenia or osteoporosis in patients showing either vitamin D insufficiency or deficiency.

CONCLUSION:

The possibility of vitamin D deficiency can be considered in pediatric patients taking anticonvulsants if they have mental retardation or developmental delay or if they have been taking anticonvulsants for more than 2 years or taking hepatic enzyme inducing drugs.

KEYWORDS:

Vitamin D; anticonvulsants; developmental disabilities; epilepsy; intellectual disability

PMID:
24532512
PMCID:
PMC3936617
DOI:
10.3349/ymj.2014.55.2.417
[Indexed for MEDLINE]
Free PMC Article

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