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Adv Healthc Mater. 2014 Jul;3(7):1015-9. doi: 10.1002/adhm.201300672. Epub 2014 Feb 14.

Magnetic ligation method for quantitative detection of microRNAs.

Author information

1
Center for Systems Biology, Massachusetts General Hospital-Harvard Medical School, 185 Cambridge St., Boston, MA, 02114, USA.

Abstract

A magnetic ligation method is utilized for the detection of microRNAs among a complex biological background without polymerase chain reaction or nucleotide modification. The sandwich probes assay can be adapted to analyze a panel of microRNAs associated with cardiovascular diseases in heart tissue samples.

KEYWORDS:

diagnostics; enzymatic ligation; magnetic labeling; magnetic resonance; microRNA

PMID:
24532323
PMCID:
PMC4107040
DOI:
10.1002/adhm.201300672
[Indexed for MEDLINE]
Free PMC Article

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