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Inflammation. 2014 Aug;37(4):1191-9. doi: 10.1007/s10753-014-9845-x.

Effects of honokiol on sepsis-induced acute kidney injury in an experimental model of sepsis in rats.

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1
Graduate School of Dalian Medical University, Dalian, 116044, People's Republic of China.

Abstract

Acute kidney injury (AKI) is a severe complication of sepsis, which largely contributes to the high mortality rate of sepsis. Honokiol, a natural product isolated from Magnolia officinalis (Houpo), has been shown to exhibit anti-inflammatory and antioxidant properties. Here, we investigated the effects of honokiol on sepsis-associated AKI in rats subjected to cecal ligation and puncture (CLP). We found that the administration of honokiol improved the survival of septic rats. Periodic acid-Schiff stain revealed that the morphological changes of kidney tissues in CLP rats were restored after honokiol treatment. Furthermore, honokiol reduced CLP-induced oxidative stress and inflammatory cytokine production. The levels of nitric oxide (NO) and inducible NO synthetase (iNOS) were attenuated by honokiol in septic rats. Finally, honokiol inhibited CLP-induced activation of NF-κB signaling in CLP rats. Our findings suggest that honokiol might be used as a potential therapeutic agent for complications of sepsis, especially for sepsis-induced AKI.

PMID:
24531855
DOI:
10.1007/s10753-014-9845-x
[Indexed for MEDLINE]

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