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Nat Mater. 2014 Mar;13(3):308-16. doi: 10.1038/nmat3878. Epub 2014 Feb 16.

Guiding intracortical brain tumour cells to an extracortical cytotoxic hydrogel using aligned polymeric nanofibres.

Author information

1
1] Neurological Biomaterials and Cancer Therapeutics Laboratory, Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology/Emory University School of Medicine, 313 Ferst Drive, Atlanta Georgia 30332 USA [2].
2
Neurological Biomaterials and Cancer Therapeutics Laboratory, Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology/Emory University School of Medicine, 313 Ferst Drive, Atlanta Georgia 30332 USA.
3
Department of Neurosurgery Children's Health Care of Atlanta Georgia 30342 USA.
4
Department of Pediatrics, Aflac Cancer And Blood Disorders Center Emory University School of Medicine Atlanta, Georgia 30322 USA.

Abstract

Glioblastoma multiforme is an aggressive, invasive brain tumour with a poor survival rate. Available treatments are ineffective and some tumours remain inoperable because of their size or location. The tumours are known to invade and migrate along white matter tracts and blood vessels. Here, we exploit this characteristic of glioblastoma multiforme by engineering aligned polycaprolactone (PCL)-based nanofibres for tumour cells to invade and, hence, guide cells away from the primary tumour site to an extracortical location. This extracortial sink is a cyclopamine drug-conjugated, collagen-based hydrogel. When aligned PCL-nanofibre films in a PCL/polyurethane carrier conduit were inserted in the vicinity of an intracortical human U87MG glioblastoma xenograft, a significant number of human glioblastoma cells migrated along the aligned nanofibre films and underwent apoptosis in the extracortical hydrogel. Tumour volume in the brain was significantly lower following insertion of aligned nanofibre implants compared with the application of smooth fibres or no implants.

PMID:
24531400
DOI:
10.1038/nmat3878
[Indexed for MEDLINE]

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