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Bioarchitecture. 2014 Jan-Feb;4(1):35-8. doi: 10.4161/bioa.28204. Epub 2014 Feb 14.

Getting myosin-V on the right track: tropomyosin sorts transport in yeast.

Author information

1
Department of Molecular Physiology & Biophysics; University of Vermont; Burlington, VT USA.

Abstract

Recent studies have revealed a novel mechanism of myosin regulation in which the actin-binding protein tropomyosin converts atypical type-V myosins into processive cargo transporters. To achieve this, tropomyosin's primary role appears to lie in its ability to influence myosin's enzyme kinetics, prolonging the strong actin-bound ADP/apo state to enable hand-over-hand walking of myosin-V dimers along actin tracks. Activation of myosin-V mediated transport by tropomyosin underscores its function in helping to direct cargos to specific actin tracks and subcellular destinations. This type of regulation supports the broader notion that tropomyosin plays a key role in actomyosin sorting.

KEYWORDS:

actin; actomyosin sorting; duty ratio; intracellular transport; myosin-V; processivity; tropomyosin

PMID:
24531330
PMCID:
PMC4199802
DOI:
10.4161/bioa.28204
[Indexed for MEDLINE]
Free PMC Article
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