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Atherosclerosis. 2014 Apr;233(2):410-4. doi: 10.1016/j.atherosclerosis.2014.01.025. Epub 2014 Jan 23.

Cardiovascular biomarkers in vertically HIV-infected children without metabolic abnormalities.

Author information

1
Laboratorio de InmunoBiología Molecular, Instituto de Investigación Sanitaria Hospital Gregorio Marañón (IISHGM), C/ Dr Esquerdo 46, 28007 Madrid, Spain. Electronic address: tsaincosta@gmail.com.
2
Laboratorio de InmunoBiología Molecular, Instituto de Investigación Sanitaria Hospital Gregorio Marañón (IISHGM), C/ Dr Esquerdo 46, 28007 Madrid, Spain.
3
Servicio de Pediatría, Hospital Gregorio Marañón, 28007 Madrid, Spain.
4
Unidad de Inmunodeficiencias pediátricas, Servicio de Pediatría, Hospital Universitario Doce de Octubre, 28026 Madrid, Spain.
5
Servicio de Pediatría, Hospital de Getafe, 28905 Madrid, Spain.
6
Servicio de Pediatría, Hospital Infantil La Paz, 28040 Madrid, Spain.
7
Servicio de Enfermedades Infecciosas e IRYCIS, Hospital Ramón y Cajal, 28034 Madrid, Spain.
8
Servicio de Pediatría, Hospital Carlos III, 28029 Madrid, Spain.
9
Laboratorio de InmunoBiología Molecular, Instituto de Investigación Sanitaria Hospital Gregorio Marañón (IISHGM), C/ Dr Esquerdo 46, 28007 Madrid, Spain. Electronic address: mmunoz.hgugm@gmail.com.

Abstract

Early cardiovascular disease is a major concern for ART-suppressed vertically HIV-infected children; however, evidence is lacking regarding specific preventive measures. In this study, a complete panel of biomarkers was determined together with carotid intima-media thickness (IMT), in a cohort of 64 HIV-infected children and 30 controls. Mean age of participants was 14.1±5 years. HIV-infected patients showed normal lipid profile, with only slightly higher triglycerides, and no differences between groups were found regarding IMT. HIV-infected patients displayed higher levels of soluble CD14 (sCD14) and soluble vascular cell adhesion molecule-1 (sVCAM) (all p<0.05). However, levels of C-reactive protein, interleukin-6, myeloperoxidase, monocyte chemoattractant protein-1, P-selectin and tissue plasminogen activator were similar between groups. Vertically HIV-infected subjects on ART with no significant metabolic disturbances displayed increased sCD14 and sVCAM but not up-regulation of proinflammatory pathways. Larger studies are warranted to assess the impact of a strict metabolic control on cardiovascular risk and to define specific cardiovascular disease preventive strategies in this population.

KEYWORDS:

CRP; Cardiovascular biomarkers; Cardiovascular risk; Children and adolescents; HIV; IMT; sCD14

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