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Transl Res. 2014 Aug;164(2):153-7. doi: 10.1016/j.trsl.2014.01.012. Epub 2014 Jan 25.

Maternal short-chain fatty acids are associated with metabolic parameters in mothers and newborns.

Author information

1
Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
2
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
3
Department of Nutritional Sciences, University of Toronto, Toronto, Canada.
4
Division of Endocrinology, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL.
5
Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL; Jesse Brown Veterans Affairs Medical Center, Chicago, IL. Electronic address: b-layden@northwestern.edu.

Abstract

During the course of pregnancy, dynamic remodeling of the gut microbiota occurs and contributes to maternal metabolic changes through an undefined mechanism. Because short chain fatty acids (SCFAs) are a major product of gut microbiome fermentation, we investigated whether serum SCFA levels during pregnancy are related to key metabolic parameters in mothers and newborns. In this prospective study, 20 pregnant women without gestational diabetes were evaluated at 36-38 weeks of gestation, and their newborns were assessed after parturition. In this cohort, which included normal (n = 10) and obese (n = 10) subjects based on prepregnancy body mass index, serum levels of SCFAs (acetate, propionate, and butyrate), maternal adipokines, maternal glucose, and C-peptide were measured at 36-38 weeks of gestation. Maternal weight gain and newborn anthropometrics were also determined. Data were analyzed using linear regression to test for associations, adjusting for prepregnancy obesity. In this cohort, serum acetate levels were associated with maternal weight gain and maternal adiponectin levels. In addition, serum propionate correlated negatively with maternal leptin levels, newborn length, and body weight. Taken together, this study observed that novel relationships exist among maternal SCFA levels and multiple interrelated maternal/newborn metabolic parameters.

PMID:
24530607
PMCID:
PMC4156825
DOI:
10.1016/j.trsl.2014.01.012
[Indexed for MEDLINE]
Free PMC Article

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