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Clin Chim Acta. 2014 Apr 20;431:185-91. doi: 10.1016/j.cca.2014.01.019. Epub 2014 Feb 12.

Galectin-3 in cancer.

Author information

1
The Key Laboratory of Tumor Metastasis in Liaoning Province, Department of Pathology, Dalian Medical University, 9 West, Lvshun Southern Road, Dalian 116044, China.
2
The Key Laboratory of Tumor Metastasis in Liaoning Province, Department of Pathology, Dalian Medical University, 9 West, Lvshun Southern Road, Dalian 116044, China. Electronic address: jwtang_53@sina.cn.
3
Department of Biochemistry and Molecular Biology, Dalian Medical University, 9 West, Lvshun Southern Road, Dalian 116044, China.

Abstract

Galectin-3 (Gal-3) plays important roles in cell proliferation, adhesion, differentiation, angiogenesis and apoptosis in normal and pathologic tissues. Accumulated evidences indicate that Gal-3 is closely involved in tumor cell transformation, migration, invasion and metastasis. In this review, the associations of the expression and localization of Gal-3 as well as its potential action mechanism in tumorigenesis in a variety of cancers were summarized and concluded. Gal-3 is gaining its attraction as a potential new biomarker for the diagnosis, treatment and prognosis of certain tumors.

KEYWORDS:

Cancer; Expression; Galectin-3 (Gal-3); Location; Mechanism

PMID:
24530298
DOI:
10.1016/j.cca.2014.01.019
[Indexed for MEDLINE]

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