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Trends Microbiol. 2014 Mar;22(3):120-7. doi: 10.1016/j.tim.2014.01.001. Epub 2014 Feb 13.

A neglected epidemic: fungal infections in HIV/AIDS.

Author information

1
Imperial Fungal Diseases Group, Imperial College London, Department of Infectious Diseases and Immunity, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. Electronic address: d.armstrong@imperial.ac.uk.
2
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925 Cape Town, South Africa.
3
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925 Cape Town, South Africa; Aberdeen Fungal Group, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK.

Abstract

Invasive fungal infections (IFIs) are a major cause of HIV-related mortality globally. Despite widespread rollout of combined antiretroviral therapy, there are still up to 1 million deaths annually from IFIs, accounting for 50% of all AIDS-related death. A historic failure to focus efforts on the IFIs that kill so many HIV patients has led to fundamental flaws in the management of advanced HIV infection. This review, based on the EMBO AIDS-Related Mycoses Workshop in Cape Town in July 2013, summarizes the current state of the-art in AIDS-related mycoses, and the key action points required to improve outcomes from these devastating infections.

KEYWORDS:

AIDS; HIV; fungal infection; immunity; mycoses

PMID:
24530175
DOI:
10.1016/j.tim.2014.01.001
[Indexed for MEDLINE]

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