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Biomaterials. 2014 Apr;35(13):4125-32. doi: 10.1016/j.biomaterials.2014.01.059. Epub 2014 Feb 12.

Tumor invasion unit in gastric cancer revealed by QDs-based in situ molecular imaging and multispectral analysis.

Author information

1
Department of Medical Imaging, The First Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, PR China.
2
Departments of Oncology & Pathology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, Wuhan 430071, PR China.
3
Department of General Surgery, Shanxi Dayi Hospital, Taiyuan 030001, PR China.
4
Department of Surgery, Heji Hospital Affiliated to Changzhi Medical College, Changzhi 046000, PR China.
5
Departments of Oncology & Pathology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, Wuhan 430071, PR China. Electronic address: liyansd2@163.com.
6
Department of Medical Imaging, The First Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, PR China. Electronic address: cjr.jianding@vip.163.com.

Abstract

In tumor tissues, cancer cells, tumor infiltrating macrophages and tumor neo-vessels in close spatial vicinity with one another form tumor invasion unit, which is a biologically important tumor microenvironment of metastasis to facilitate cancer invasion and metastasis. Establishing an in situ molecular imaging technology to simultaneously reveal these three components is essential for the in-depth investigation of tumor invasion unit. In this report, we have developed a computer-aided algorithm by quantum dots (QDs)-based multiplexed molecular imaging technique for such purpose. A series of studies on gastric cancer tumor tissues demonstrated that the tumor invasion unit was correlated with major unfavorable pathological features and worse clinical outcomes, which illustrated the significantly negative impacts and predictive power of tumor invasion unit on patient overall survival. This study confirmed the technical advantages of QDs-based in situ and simultaneous molecular imaging of key cancer molecules to gain deeper insights into the biology of cancer invasion.

KEYWORDS:

Gastric cancer; Molecular imaging; Multispectral analysis; Quantum dots; Tumor invasion unit; Tumor microenvironment of metastasis

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