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J Clin Virol. 2014 Apr;59(4):235-41. doi: 10.1016/j.jcv.2014.01.012. Epub 2014 Jan 26.

Hepatitis B virus prevalence, risk factors and genotype distribution in HIV infected patients from West Java, Indonesia.

Author information

1
Department of Virology, Erasmus Medical Centre, Erasmus University Rotterdam, The Netherlands; School of Life Science and Technology, Institut Teknologi Bandung, Indonesia. Electronic address: a.fibriani@erasmusmc.nl.
2
Internal Medicine Department, Hasan Sadikin Hospital-Medical Faculty, Universitas Padjadjaran Bandung, Indonesia.
3
Clinical Pathology Department, Hasan Sadikin Hospital-Medical Faculty, Universitas Padjadjaran Bandung, Indonesia.
4
Department of Virology, Erasmus Medical Centre, Erasmus University Rotterdam, The Netherlands.
5
Department of General Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.

Abstract

BACKGROUND:

Indonesia currently faces both an increasing HIV incidence and a high hepatitis B virus (HBV) burden.

OBJECTIVE:

The objective of our study is to examine the prevalence, risk factors, and genotypic distribution of HBV infection among HIV infected patients in West Java, Indonesia.

STUDY DESIGN:

A cross sectional study was conducted among a cohort of HIV infected patients in 2008. Demographic and disease related variables were compared between HBV negative and positive patients. Logistic regression was applied to determine risk factors for HBV co-infection. HBV and HIV genotyping was performed in co-infected patients.

RESULTS:

Of 636 HIV-infected patients, the rate of HBV co-infection was 7%. The proportion of males was higher in HBV/HIV co-infected patients than in HIV mono-infected patients (93% vs. 72%, P=0.001). A history of injecting drug use (IDU), but not tattooing, was associated with HBV co-infection [P=0.035 OR 2.41 (95% CI 1.06-5.47)]. In the HIV and HBV treatment naive patients, CD4 cells counts <50cells/mm(3), HIV-RNA plasma ≥10,000copies/ml and AST level above normal were more often found in patients with high HBV-DNA levels (≥20,000IU/ml) as compared to those with low HBV DNA (<20.000IU/ml) (P<0.05). As in the general population, B3 was the dominant subtype in HBV co-infected patients.

CONCLUSION:

The prevalence of active HBV infection and the genotype distribution among HIV infected individuals is similar to the overall population in Java. However, an increased prevalence was observed in men with a history of IDU, underlining the need for routine HBV screening and monitoring.

KEYWORDS:

HBV; HIV; Indonesia

PMID:
24529845
DOI:
10.1016/j.jcv.2014.01.012
[Indexed for MEDLINE]
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