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Epilepsy Behav. 2014 Sep;38:19-24. doi: 10.1016/j.yebeh.2014.01.013. Epub 2014 Feb 12.

Posttraumatic epilepsy - disease or comorbidity?

Author information

1
Epilepsy Research Laboratory, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, PO Box 1627, FIN-70211 Kuopio, Finland; Department of Neurology, Kuopio University Hospital, PO Box 1777, FIN-70211 Kuopio, Finland. Electronic address: asla.pitkanen@uef.fi.
2
Kainuu Central Hospital, Kainuu Social Welfare and Health Care Joint Authority, Kajaani, Finland; Northern Finland Laboratory Centre (NordLab), Sotkamontie 13, FIN-87300 Kajaani, Finland.
3
Epilepsy Research Laboratory, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, PO Box 1627, FIN-70211 Kuopio, Finland.
4
Biomedical Imaging Unit, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, PO Box 1627, FIN-70211 Kuopio, Finland.

Abstract

Traumatic brain injury (TBI) can cause a myriad of sequelae depending on its type, severity, and location of injured structures. These can include mood disorders, posttraumatic stress disorder and other anxiety disorders, personality disorders, aggressive disorders, cognitive changes, chronic pain, sleep problems, motor or sensory impairments, endocrine dysfunction, gastrointestinal disturbances, increased risk of infections, pulmonary disturbances, parkinsonism, posttraumatic epilepsy, or their combinations. The progression of individual pathologies leading to a given phenotype is variable, and some progress for months. Consequently, the different post-TBI phenotypes appear within different time windows. In parallel with morbidogenesis, spontaneous recovery occurs both in experimental models and in human TBI. A great challenge remains; how can we dissect the specific mechanisms that lead to the different endophenotypes, such as posttraumatic epileptogenesis, in order to identify treatment approaches that would not compromise recovery?

KEYWORDS:

Behavior; Cognitive function; Depression; Epileptogenesis; Functional magnetic resonance imaging; Memory; Recovery; Traumatic brain injury

PMID:
24529830
DOI:
10.1016/j.yebeh.2014.01.013
[Indexed for MEDLINE]

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