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Cell Rep. 2014 Feb 13;6(3):417-9. doi: 10.1016/j.celrep.2014.01.035.

Tumor evolution in response to chemotherapy: phenotype versus genotype.

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1
Department of Genetics, MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: nnavin@mdanderson.org.

Abstract

In this issue of Cell Reports, Almendro et al. report one of the first comprehensive studies on the intratumor heterogeneity of cell phenotypes and genotypes before and after chemotherapy in breast cancer. These data challenge the concept of genetic population bottlenecks and suggest that cellular phenotypes play an important role in developing resistance to therapy.

PMID:
24529750
PMCID:
PMC5558200
DOI:
10.1016/j.celrep.2014.01.035
[Indexed for MEDLINE]
Free PMC Article
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