Format

Send to

Choose Destination
See comment in PubMed Commons below
Neurobiol Aging. 2014 Jul;35(7):1744-54. doi: 10.1016/j.neurobiolaging.2014.01.012. Epub 2014 Jan 13.

Age-specific transcriptional response to stroke.

Author information

1
Hans Berger Department of Neurology, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
2
Biocontrol Jena GmbH, Jena, Germany.
3
Department of Mechanical and Process Engineering, Furtwangen University, Villingen-Schwenningen, Germany.
4
Hans Berger Department of Neurology, Jena University Hospital, Friedrich Schiller University, Jena, Germany; CSCC, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.
5
Hans Berger Department of Neurology, Jena University Hospital, Friedrich Schiller University, Jena, Germany. Electronic address: christiane.frahm@med.uni-jena.de.

Abstract

Increased age is a major risk factor for stroke incidence and post-ischemic mortality. To develop age-adjusted therapeutic interventions, a clear understanding of the complexity of age-related post-ischemic mechanisms is essential. Transient occlusion of the middle cerebral artery--a model that closely resembles human stroke--was used to induce cerebral infarction in mice of 4 different ages (2, 9, 15, 24 months). By using Illumina cDNA microarrays and quantitative PCR we detected a distinct age-dependent response to stroke involving 350 differentially expressed genes. Our analyses also identified 327 differentially expressed genes that responded to stroke in an age-independent manner. These genes are involved in different aspects of the inflammatory and immune response, oxidative stress, cell cycle activation and/or DNA repair, apoptosis, cytoskeleton reorganization and/or astrogliosis, synaptic plasticity and/or neurotransmission, and depressive disorders and/or dopamine-, serotonin-, GABA-signaling. In agreement with our earlier work, aged brains displayed an attenuated inflammatory and immune response (Sieber et al., 2011) and a reduced impairment of post-stroke synaptic plasticity. Our data also revealed a distinct age-related susceptibility for post-ischemic depression, the most common neuropsychiatric consequence of stroke, which has a major influence on functional outcome.

KEYWORDS:

Aging; Depression; Inflammation; MCAO

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center