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Med Gas Res. 2014 Feb 14;4(1):2. doi: 10.1186/2045-9912-4-2.

Adverse effect of inhalational anesthetics on the developing brain.

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Department of Anesthesiology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.


We did a PubMed search and summarized studies on the potential adverse effect of anesthetics especially neurotoxicity in the developing brain, so named anesthesia-induced developmental neurotoxicity. Even though many experimental studies using animal models indicated some adverse effect of anesthetics, more evidence is needed before a recommendation can be made to change the way those anesthetics are used in the pediatric population. Two large clinical trials are underway and may provide insight to the potential human neurotoxic effect of anesthetics.

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