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J Integr Plant Biol. 2014 Jun;56(6):518-26. doi: 10.1111/jipb.12185. Epub 2014 Mar 13.

Homeodomain leucine-zipper proteins and their role in synchronizing growth and development with the environment.

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Center for Plant Molecular Biology, University of Tübingen, Germany; Leibniz Institute of Plant Genetics and Crop Plant Research, Gatersleben, Germany.


The Arabidopsis (Arabidopsis thaliana L.) genome encodes for four distinct classes of homeodomain leucine-zipper (HD-ZIP) transcription factors (HD-ZIPI to HD-ZIPIV), which are all organized in multi-gene families. HD-ZIP transcription factors act as sequence-specific DNA-binding proteins that are able to control the expression level of target genes. While HD-ZIPI and HD-ZIPII proteins are mainly associated with environmental responses, HD-ZIPIII and HD-ZIPIV are primarily known to act as patterning factors. Recent studies have challenged this view. It appears that several of the different HD-ZIP families interact genetically to align both morphogenesis and environmental responses, most likely by modulating phytohormone-signaling networks.


KANADI; REVOLUTA; Transcription factors; abscisic acid; auxin; homeodomain; leaf development; leucine zipper; light signaling; microRNA; water stress

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