Format

Send to

Choose Destination
Clin Exp Immunol. 2014 Jul;177(1):24-9. doi: 10.1111/cei.12293.

Intestinal microbiota and faecal transplantation as treatment modality for insulin resistance and type 2 diabetes mellitus.

Author information

1
Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

Abstract

The prevalence of obesity and diabetes mellitus type 2 is increasing rapidly around the globe. Recent insights have generated an entirely new perspective that the intestinal microbiota may play a significant role in the development of these metabolic disorders. Alterations in the intestinal microbiota composition promote systemic inflammation that is a hallmark of obesity and subsequent insulin resistance. Thus, it is important to understand the reciprocal relationship between intestinal microbiota composition and metabolic health in order to eventually prevent disease progression. In this respect, faecal transplantation studies have implicated that butyrate-producing intestinal bacteria are crucial in this process and be considered as key players in regulating diverse signalling cascades associated with human glucose and lipid metabolism.

KEYWORDS:

diabetes; host-pathogen interactions; lipopolysaccharide

PMID:
24528224
PMCID:
PMC4089151
DOI:
10.1111/cei.12293
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center