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Circ Res. 2014 Feb 14;114(4):730-7. doi: 10.1161/CIRCRESAHA.114.300505.

Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease.

Author information

1
From the Department of Pharmacology, LSU Health Sciences Center, New Orleans, LA (D.J.P., D.J.L.); and the LSU Cardiovascular Center of Excellence, New Orleans, LA (D.J.P., D.J.L.).

Abstract

Long recognized as a malodorous and highly toxic gas, recent experimental studies have revealed that hydrogen sulfide (H2S) is produced enzymatically in all mammalian species including man and exerts several critical actions to promote cardiovascular homeostasis and health. During the past 15 years, scientists have determined that H2S is produced by 3 endogenous enzymes and exerts powerful effects on endothelial cells, smooth muscle cells, inflammatory cells, mitochondria, endoplasmic reticulum, and nuclear transcription factors. These effects have been reported in multiple organ systems, and the majority of data clearly indicate that H2S produced by the endogenous enzymes exerts cytoprotective actions. Recent preclinical studies investigating cardiovascular diseases have demonstrated that the administration of physiological or pharmacological levels of H2S attenuates myocardial injury, protects blood vessels, limits inflammation, and regulates blood pressure. H2S has emerged as a critical cardiovascular signaling molecule similar to nitric oxide and carbon monoxide with a profound effect on the heart and circulation. Our improved understanding of how H2S elicits protective actions, coupled with the rapid development of novel H2S-releasing agents, has resulted in heightened enthusiasm for the clinical translation of this ephemeral gaseous molecule. This review will examine our current state of knowledge about the actions of H2S within the cardiovascular system with an emphasis on the therapeutic potential and molecular cross talk between H2S, nitric oxide, and carbon monoxide.

KEYWORDS:

carbon monoxide; gasotransmitters; heart failure; nitric oxide

PMID:
24526678
PMCID:
PMC3951140
DOI:
10.1161/CIRCRESAHA.114.300505
[Indexed for MEDLINE]
Free PMC Article

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