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Nutr Neurosci. 2015 Jan;18(1):37-40. doi: 10.1179/1476830514Y.0000000109. Epub 2014 Feb 14.

Intracranial volume inversely correlates with serum 25(OH)D level in healthy young women.

Abstract

OBJECTIVES:

Vitamin D is important in normal brain development. In animals low vitamin D level is associated with brain morphological alterations including enlargement of the brain. Whether a similar association exists in humans is unknown. Here we investigated the relationship between vitamin D and total intracranial volume as well as total volume of the cortical grey and cerebral white matter and that of the ventricles in young healthy women.

METHODS:

To assess volumes we applied semi-automatic user-independent MR volumetry. For the vitamin D measurements automated electrochemiluminescence immunoassay was used.

RESULTS:

We found a significant negative correlation between vitamin D and total intracranial volume as well as total cortical grey and cerebral white matter volumes.

DISCUSSION:

This association may reflect a trait-like relationship between vitamin D and brain size possibly determined in early development.

KEYWORDS:

25(OH)D; Brain volumetry; Intracranial volume; MRI; Vitamin D

PMID:
24524629
DOI:
10.1179/1476830514Y.0000000109
[Indexed for MEDLINE]
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