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Clin Perinatol. 2014 Mar;41(1):229-39. doi: 10.1016/j.clp.2013.10.007. Epub 2013 Dec 15.

Neurogenesis and maturation in neonatal brain injury.

Author information

1
Child Study Center, Yale University, 230 South Frontage Road, New Haven, CT 06520, USA.
2
Child Study Center, Yale University, 230 South Frontage Road, New Haven, CT 06520, USA; Department of Neurobiology, Kavli Institute for Neuroscience, Yale University, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address: flora.vaccarino@yale.edu.

Abstract

The incidence of preterm birth is on the rise. The outcome of premature birth can vary widely, spanning completely normal development to severe neurologic deficits, with most children showing mild to moderate cognitive delay and increased incidence of neuropsychiatric conditions such as anxiety, attention deficit hyperactivity, and autism spectrum disorders. Several animal models have been employed to study the consequences of prematurity, one of the most promising being chronic perinatal hypoxia in mouse, which recapitulates the cognitive impairments, partial recovery over time and enhanced recovery with environmental enrichment.

KEYWORDS:

Cognitive delay; Neonatal brain injury; Neurogenesis; Preterm birth

PMID:
24524457
PMCID:
PMC3925307
DOI:
10.1016/j.clp.2013.10.007
[Indexed for MEDLINE]
Free PMC Article

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