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Clin Perinatol. 2014 Mar;41(1):149-59. doi: 10.1016/j.clp.2013.10.008.

Outcomes of hypoxic-ischemic encephalopathy in neonates treated with hypothermia.

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Division of Neonatal/Perinatal Medicine, Children's Hospital of Michigan, 3901 Beaubien, Detroit, MI, USA. Electronic address:


This article examines the evidence regarding mortality and neurodevelopmental outcomes following hypothermia for neonatal hypoxic-ischemic encephalopathy. Data from randomized controlled trials regarding neurodevelopmental outcome at the end point of the major trials, and from 2 of the trials on childhood outcome following hypothermia for neonatal hypoxic-ischemic encephalopathy are presented. The predictors of outcome that can be evaluated in the neonatal period are also reviewed, as this information may assist in the counseling of families. Most trials of hypothermia have been performed in high-resource countries; published studies from the low- and middle-income countries are also reviewed.

TRIAL REGISTRATION: NCT00620711 NCT00719407 NCT00934700 NCT01192776 NCT01241019 NCT01545271.


Encephalopathy; Hypothermia; Neonatal; Outcome; Predictors

[Indexed for MEDLINE]

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