Format

Send to

Choose Destination
See comment in PubMed Commons below
Iran J Pharm Res. 2013 Fall;12(4):845-53.

Effect of single dose administration of methylsulfonylmethane on oxidative stress following acute exhaustive exercise.

Author information

  • 1Department of Exercise Physiology, Ardabil Branch, Islamic Azad University, Iran.
  • 2Department of Exercise Physiology, University of Mohaghegh-Ardabili, Ardabil, Iran.
  • 3Department of Pharmacology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran.

Abstract

Methylsulfonylmethane (MSM) is a sulfur-containing compound commonly found in diet and known to reduce oxidative stress. This trial was conducted to determine whether single dose supplementation with MSM attenuates post-exercise oxidative stress in healthy untrained young men. Sixteen untrained men volunteered for this study. Participants were randomized in a double-blind placebo-controlled fashion into 2 groups: Methylsulfonylmethane (MSM) (n = 8) and placebo (n = 8). The participants took supplementation or placebo before running on treadmill for 45 min at 75% VO2max. The MSM supplementation was prepared in water as 100 mg/ kg body weight. The placebo group received water. Serum Malondealdehyde (MDA), uric acid, bilirubin, protein carbonyl (PC) and plasma vitamin E levels were determined as the markers of oxidative stress. Plasma GSH (reduced Glutathione) and total antioxidant capacity (TAC) were measured as markers of plasma antioxidant system. MSM supplementation successfully lowered serum PC 2 and 24 h after exercise. Plasma TAC in MSM group was higher at 24 h after exercise. Serum level of uric acid and bilirubin were significantly low immediately after exercise in MSM supplemented group. There was no significant difference between groups in terms of plasma GSH level. These results complement earlier studies showing anti-oxidant effect of MSM and suggest that single dose oral supplementation with MSM lowers exercise induced oxidative stress in healthy untrained young men, but is not adequate to significantly affect plasma GSH level.

KEYWORDS:

Antioxidant; Bilirubin; GSH; MDA; MSM; Protein carbonylation; TAC; Uric acid

PMID:
24523764
PMCID:
PMC3920715
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center