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Front Cell Neurosci. 2014 Jan 30;8:15. doi: 10.3389/fncel.2014.00015. eCollection 2014.

The role of miRNA in motor neuron disease.

Author information

1
Institute of Human Genetics, University of Cologne Cologne, Germany ; Institute for Genetics, University of Cologne Cologne, Germany.

Abstract

microRNA is a subset of endogenous non-coding RNA. It binds to partially complementary sequences in mRNAs and inhibits mRNA translation by either blocking translational machinery or degrading mRNAs. It is involved in various cellular processes including cell cycle, development, metabolism, and synaptic plasticity. Dysregulation of miRNA expression and function is reported in various diseases including cancer, metabolic disorders as well as neurological disorders. In nervous system, miRNA related pathways play a very important role in development and function of neuronal cells. Moreover, numerous evidences suggest that dysregulated miRNA related pathways contribute to pathology of neurological disorders such as Alzheimer's disease, amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Here, we review current knowledge about the role of miRNAs in motor neuron disorders, especially about two common diseases: SMA and ALS.

KEYWORDS:

amyotrophic lateral sclerosis; microRNA; motor neurons; neuromuscular junction; spinal muscular atrophy

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