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ScientificWorldJournal. 2014 Jan 12;2014:357403. doi: 10.1155/2014/357403. eCollection 2014.

Anticonvulsant potential of certain new (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides.

Author information

1
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia ; Pharmaceutical and Drug Industries Research Division, Medicinal and Pharmaceutical Chemistry Department (Medicinal Chemistry Group), National Research Centre, Dokki, Giza 12622, Egypt.
2
Pharmaceutical and Drug Industries Research Division, Medicinal and Pharmaceutical Chemistry Department (Medicinal Chemistry Group), National Research Centre, Dokki, Giza 12622, Egypt.
3
Pharmaceutical and Drug Industries Research Division, Medicinal and Pharmaceutical Chemistry Department (Pharmacology Group), National Research Centre, Dokki, Giza 12622, Egypt.
4
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

Abstract

Anticonvulsant potential and neurotoxicity of certain new imidazole-containing arylsemicarbazones 6a-p are reported. The test compounds 6a-p exhibited anticonvulsant activity mainly in the scPTZ screen. Compound 6p emerged as the most active surrogate displaying 100% protection at a dose level of 636 μ mol/kg in the scPTZ screen without any neurotoxicity. The assigned (E)-configuration of the title compounds 6a-p was confirmed via single crystal X-ray structure of compound 6g.

PMID:
24523636
PMCID:
PMC3913509
DOI:
10.1155/2014/357403
[Indexed for MEDLINE]
Free PMC Article

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