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J Patient Saf. 2014 Mar;10(1):59-63. doi: 10.1097/PTS.0000000000000050.

Core drug-drug interaction alerts for inclusion in pediatric electronic health records with computerized prescriber order entry.

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From the *Divisions of Emergency Medicine and Infectious Diseases, Boston Children's Hospital Boston, MA, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; †Department of Clinical Informatics, Lucile Packard Children's Hospital; ‡Department of Pediatrics, Stanford School of Medicine, Palo Alto, California; §Hospitalist Division, Seattle Children's Hospital and Department of Pediatrics, University of Washington, Seattle, Washington; ∥Division of Pediatric Critical Care, Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota; ¶Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and #Department of Pharmacy, Boston Children's Hospital, Boston, Massachusetts.



The study aims to develop a core set of pediatric drug-drug interaction (DDI) pairs for which electronic alerts should be presented to prescribers during the ordering process.


A clinical decision support working group composed of Children's Hospital Association (CHA) members was developed. CHA Pharmacists and Chief Medical Information Officers participated.


Consensus was reached on a core set of 19 DDI pairs that should be presented to pediatric prescribers during the order process.


We have provided a core list of 19 high value drug pairs for electronic drug-drug interaction alerts to be recommended for inclusion as high value alerts in prescriber order entry software used with a pediatric patient population. We believe this list represents the most important pediatric drug interactions for practical implementation within computerized prescriber order entry systems.

[Indexed for MEDLINE]

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