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Zhonghua Yi Xue Za Zhi. 2013 Nov 26;93(44):3520-2.

[Value of combined detection of urinary Livin and Survivin mRNA expression in the early diagnosis of bladder cancer].

[Article in Chinese]

Author information

1
Department of Urology, Fourth Affiliated Hospital, Nanchang University, Nanchang 330002, China.
2
Department of Urology, Fourth Affiliated Hospital, Nanchang University, Nanchang 330002, China. Email: 914002489@qq.com.

Abstract

OBJECTIVE:

To evaluate the value of urine Livin and Survivin mRNA expression in the early diagnosis of bladder cancer.

METHODS:

Fifty-two cases of early bladder cancer and 30 cases of non-urinary system tumors were selected for the combined detection of urinary Livin and Survivin and urine cytology.

RESULTS:

Livin and Survivin in urine and urinary cytology sensitivity were 71.2% (37/52) , 67.3% (35/52), 23.1% (12/52); Specificity were 96.7% (29/30) , 93.3% (28/30) and 96.7% (29/30) respectively. Urine Survivin sensitivity, specificity compared with Livin were no significant difference (all P > 0.05). Urinary Livin and Survivin were more sensitive than urine cytology, and the differences were statistically significant(all P < 0.05).

CONCLUSION:

The combined urinary detection of Livin, Survivin mRNA expression is a noninvasive early diagnosis of bladder cancer with sensitivity and specificity.

PMID:
24521893
[Indexed for MEDLINE]
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