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Zhonghua Yi Xue Za Zhi. 2013 Nov 26;93(44):3500-5.

[Ten-day sequential therapy for Helicobacter pylori eradication in children: a systematic review of randomized controlled trials].

[Article in Chinese]

Author information

1
Department of Gastroenterology, Second Municipal People's Hospital, Ya'an 625000, China. Email: hjdshare@sina.com.
2
Department of Gastroenterology, Second Municipal People's Hospital, Ya'an 625000, China.

Abstract

OBJECTIVE:

To assess the efficacy and safety of 10-day sequential therapy for Helicobacter pylori (H.pylori) eradication in children.

METHODS:

The databases of Cochrane Central Register of Controlled Trials (CENTRAL, 2013,N01), Medline, Embase, OVID, Chinese Biological Medicine database (CBMDisc), CNKI, Chinese VIP and WANFANG (all from 2000-2013) were searched. And manual searches were performed for the relevant journals and conference proceedings. Prospective, randomized controlled trials of 10-day sequential therapy for H.pylori eradication in children were selected. The systematic review was conducted with the method recommended by The Cochrane Collaboration.

RESULTS:

Fifteen trials with a total of 1348 patients were included for analysis. The meta-analysis showed: (1) H.pylori eradication rates: 10-day sequential therapy were superior to triple therapy (80.78% (521/645) vs 69.84% (491/703), OR 2.13, 95%CI: 1.62-2.80, P < 0.01). It was also superior to 7-day and 10-day standard triple therapy (86.03% (271/315) vs 73.77% (225/305), 79.04% (181/229) vs 65.19% (176/270); OR 2.23, 2.11; 95%CI:1.47-3.36, 1.37-3.24;both P < 0.01) . There were non-superior to 14-day standard triple therapy (73.97% (108/146) vs 70.31% (90/128), OR 1.87, 95%CI: 0.46-7.69, P = 0.38). (2) Adverse effect rate: adverse events were similar between sequential and standard triple therapies (P = 0.58).

CONCLUSION:

The 10-day sequential therapy may be a new effective and safe option in treatment of H.pylori infections in children.

PMID:
24521889
[Indexed for MEDLINE]
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