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EMBO Mol Med. 2014 Mar;6(3):297-8. doi: 10.1002/emmm.201303730. Epub 2014 Feb 12.

VEGF-B: a more balanced approach toward cardiac neovascularization?

Author information

1
Medizinische Klinik I Klinikum Großhadern, Munich, Germany.

Abstract

There is an urgent need for new pharmacologic approaches to combat the clinical consequences of ischemic cardiomyopathy. In this issue of EMBO Molecular Medicine, Kivelä et al show that transgenic expression of VEGF-B in the rat heart leads to expansion of the coronary arterial tree and an increase in functional coronary reserve, accompanied by a shift in myocardial metabolism from fatty acid to glucose utilization.

PMID:
24521742
PMCID:
PMC3958304
DOI:
10.1002/emmm.201303730
[Indexed for MEDLINE]
Free PMC Article

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