Dual responsive supramolecular nanogels for intracellular drug delivery

Chem Commun (Camb). 2014 Apr 14;50(29):3789-91. doi: 10.1039/c4cc00016a. Epub 2014 Feb 12.

Abstract

Supramolecular nanogels cross-linked by host-guest interaction between dextran grafted benzimidazole (Dex-g-BM) and thiol-β-cyclodextrin were designed. Their special supramolecular pH-sensitivity under acidic conditions (pH < 6, within the range of malignant cellular endosomes) and reduction sensitivity in response to biologically relevant stimuli will be of great advantage to the future of cancer chemotherapeutics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / toxicity
  • Cell Survival / drug effects
  • Doxorubicin / chemistry
  • Doxorubicin / toxicity
  • Drug Carriers / chemistry*
  • HeLa Cells
  • Hep G2 Cells
  • Humans
  • Hydrogen-Ion Concentration
  • Nanogels
  • Polyethylene Glycols / chemistry*
  • Polyethyleneimine / chemistry*
  • beta-Cyclodextrins / chemistry

Substances

  • Antibiotics, Antineoplastic
  • Drug Carriers
  • Nanogels
  • beta-Cyclodextrins
  • polyethylene glycol polyethyleneimine nanogel
  • Polyethylene Glycols
  • Doxorubicin
  • Polyethyleneimine
  • betadex