Abstract
Supramolecular nanogels cross-linked by host-guest interaction between dextran grafted benzimidazole (Dex-g-BM) and thiol-β-cyclodextrin were designed. Their special supramolecular pH-sensitivity under acidic conditions (pH < 6, within the range of malignant cellular endosomes) and reduction sensitivity in response to biologically relevant stimuli will be of great advantage to the future of cancer chemotherapeutics.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibiotics, Antineoplastic / chemistry
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Antibiotics, Antineoplastic / toxicity
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Cell Survival / drug effects
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Doxorubicin / chemistry
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Doxorubicin / toxicity
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Drug Carriers / chemistry*
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HeLa Cells
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Hep G2 Cells
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Humans
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Hydrogen-Ion Concentration
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Nanogels
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Polyethylene Glycols / chemistry*
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Polyethyleneimine / chemistry*
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beta-Cyclodextrins / chemistry
Substances
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Antibiotics, Antineoplastic
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Drug Carriers
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Nanogels
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beta-Cyclodextrins
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polyethylene glycol polyethyleneimine nanogel
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Polyethylene Glycols
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Doxorubicin
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Polyethyleneimine
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betadex