Format

Send to

Choose Destination
Fortschr Neurol Psychiatr. 2014 Feb;82(2):78-83. doi: 10.1055/s-0033-1356123. Epub 2014 Feb 11.

[Folates in the treatment of depression].

[Article in German]

Author information

1
Klinik für Psychiatrie, Psychotherapie und Psychosomatik, Martin Gropius Krankenhaus, I. Psychiatrische Klinik, Eberswalde.
2
Abteilung für Psychiatrie, Schlosspark-Klinik, Berlin.

Abstract

Depression is an important and often recurrent illness. An initial antidepressant trial is effective at achieving remission for about 30 % of patients when prescribed as monotherapy, with the majority of patients returning as partial or non-responders. Suboptimal serum and red blood cell folate levels have been associated with a poorer response to antidepressant therapy, a greater severity of symptoms, later onset of clinical improvement, and overall treatment resistance. This article reviews the evidence for L-methylfolate and folic acid as antidepressive agents in depression and discusses their clinical use.

PMID:
24519190
DOI:
10.1055/s-0033-1356123
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Georg Thieme Verlag Stuttgart, New York
Loading ...
Support Center