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Br J Cancer. 2014 Apr 2;110(7):1891-7. doi: 10.1038/bjc.2014.66. Epub 2014 Feb 11.

Breast cancer: trends in international incidence in men and women.

Author information

1
Department of Public Health Science, School of Public Health, University of Alberta 3-381 Edmonton Clinic Health Academy, 11405 87th Avenue, Edmonton Alberta T6G 1C9, Canada.
2
Wayne Francis Cancer Epidemiology Research Group, School of Health Sciences, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand.
3
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M4B402, Seattle, WA 98109, USA.

Abstract

BACKGROUND:

The age-standardised incidence of breast cancer varies geographically, with rates in the highest-risk countries more than five times those in the lowest-risk countries.

METHODS:

We investigated the correlation between male (MBC) and female breast cancer (FBC) incidence stratified by female age-group (<50 years, and ≥50 years) and used Poisson regression to examine male incidence rate ratios according to female incidence rates.

RESULTS:

Age-adjusted breast cancer incidence rates for males and females share a similar geographic distribution (Spearman's correlation=0.51; P<0.0001). A correlation with male incidence rates was found for the entire female population and for women aged 50 years and over. Breast cancer incidence rates in males aged <50 years were not associated with FBC incidence, whereas those in males aged 50 years were. MBC incidence displays a small 'hook' similar to the Clemmesen's hook for FBC, but at a later age than the female hook.

INTERPRETATION:

Further investigation of possible explanations for these patterns is warranted. Although the incidence of breast cancer is much lower in men than in women, it may be possible to identify a cause common to both men and women.

PMID:
24518595
PMCID:
PMC3974084
DOI:
10.1038/bjc.2014.66
[Indexed for MEDLINE]
Free PMC Article

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