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Gut Liver. 2014 Jan;8(1):1-6. doi: 10.5009/gnl.2014.8.1.1. Epub 2014 Jan 13.

Clostridium difficile infection: a worldwide disease.

Author information

1
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Abstract

Clostridium difficile, an anaerobic toxigenic bacterium, causes a severe infectious colitis that leads to significant morbidity and mortality worldwide. Both enhanced bacterial toxins and diminished host immune response contribute to symptomatic disease. C. difficile has been a well-established pathogen in North America and Europe for decades, but is just emerging in Asia. This article reviews the epidemiology, microbiology, pathophysiology, and clinical management of C. difficile. Prompt recognition of C. difficile is necessary to implement appropriate infection control practices.

KEYWORDS:

Asia; Clostridium difficile; Epidemiology; Review

PMID:
24516694
PMCID:
PMC3916678
DOI:
10.5009/gnl.2014.8.1.1
[Indexed for MEDLINE]
Free PMC Article

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