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J Res Med Sci. 2013 Jul;18(7):601-10.

Pharmacokinetic drug-drug interaction and their implication in clinical management.

Author information

1
Department of Health Science, School of Medicine, University of Catanzaro, Rete Regionale di Informazione Sul Farmaco, AO MaterDomini Catanzaro, Italy.
2
Department of Clinical and Experimental Medicine, Division of Pharmacology, University of Pisa, Italy.
3
Azienda Sanitaria Provinciale Catanzaro, Department of Primary Care, Italy.
4
Department of Neurology, Cosenza Hospital, Italy.

Abstract

Drug-drug interactions (DDIs) are one of the commonest causes of medication error in developed countries, particularly in the elderly due to poly-therapy, with a prevalence of 20-40%. In particular, poly-therapy increases the complexity of therapeutic management and thereby the risk of clinically important DDIs, which can both induce the development of adverse drug reactions or reduce the clinical efficacy. DDIs can be classify into two main groups: pharmacokinetic and pharmacodynamic. In this review, using Medline, PubMed, Embase, Cochrane library and Reference lists we searched articles published until June 30 2012, and we described the mechanism of pharmacokinetic DDIs focusing the interest on their clinical implications.

KEYWORDS:

Absorption; adverse drug reaction; distribution; drug-drug interactions; excretion; metabolism; poly-therapy

PMID:
24516494
PMCID:
PMC3897029

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